Stelios Andreadis

PhD

photo of Stelios.

Stelios Andreadis

PhD

Stelios Andreadis

PhD

SUNY Distinguished Professor
Director - Cell, Gene and Tissue Engineering Center

Research Topics

Stem cells for vascular tissue engineering; signaling pathways in cell-cell adhesion and wound healing; lentiviral vectors and lentiviral microarrays for high-throughput gene expression analysis and gene discovery

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Research Overview

Andreadis research group, taken at 2021 graduate research symposium.

Andreadis research group, taken at 2021 graduate research symposium 

Research work in my laboratory spans a wide spectrum from fundamental to technological to pre-clinical/translational research. It is highly interdisciplinary, and is facilitated by collaboration with researchers from the School of Medicine (Pediatrics, Physiology and Biophysics); Dental School (Oral Biology); Center of Excellence in Bioinformatics and Life Sciences; Roswell Park Cancer Institute (RPCI) and Biomedical Engineering. To date our work has resulted in 105 peer-reviewed publications, 32 conference proceedings, 74 invited presentations and over 250 conference presentations. Our work has been continuously funded over the years from federal, state and private foundation sources including NIH, NSF, the New York State Stem Cell Fund (NYSTEM), JDRF, the John R. Oishei Foundation and the Whittaker Foundation. Recently, I led a team of UB and RPCI investigators that was awarded a grant from NYSTEM to launch a new Training Program focusing on Stem Cells in Regenerative Medicine (SCiRM).

Research Interests

  • Adult and induced pluripotent stem (iPS) cells for cardiovascular tissue engineering
  • Direct cell reprogramming to neural crest stem cells and associated lineages
  • Systems bioengineering of gene regulatory networks in stem cell engineering through development of a novel technology - LentiViral Arrays (LVA) for real-time monitoring of stem cell behavior
  • Intercellular adhesion signaling in epithelial development and stem cell differentiation
  • Molecular engineering of biomimetic biomaterials for protein and gene delivery

Research projects

  • The Andreadis group aims to understand methods to engineer small-diameter, transplantable blood vessels using adult mesenchymal stem cells from bone marrow, hair follicles, and human iPSC.
  • The Stelios Andreadis research group has discovered that introduction of a single pluripotency gene, Nanog reversed the effects of cellular senescence and restored the ability of MSCs to generate contractile force.
  • The Stelios Andreadis research group has identified cell-cell adhesion as an important factor determining MSC differentiation.
  • The Andreadis laboratory discovered a population of neural crest like stem cells in cultures of postnatal human epidermal keratinocytes (they were termed as KC-NC) by mimicking signaling events that occur at the neural plate border.
  • The Stelios Andreadis laboratory has developed novel methods to deliver growth factors, genes and recombinant viruses for multiple applications ranging from wound healing, vascular tissue engineering, lentiviral arrays and gland regeneration.